GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs13014235 | 1 | rs6435081 | chr2:202220623 | PPIL3 | chr2:201735680-201753999:- | -0.24 | -4.92 | 1.19E-6 | Basal cell carcinoma |
| THCA | cis | rs7582720 | 1 | rs6435169 | chr2:203753016 | ALS2CR8 | chr2:203776978-203851060:+ | -0.29 | -5.93 | 5.93E-9 | Coronary artery disease or large artery stroke;Coronary artery disease or ischemic stroke |
| THCA | cis | rs7582720 | 1 | rs6435169 | chr2:203753016 | ICA1L | chr2:203637873-203736371:- | 0.25 | 4.18 | 3.49E-5 | Coronary artery disease or large artery stroke;Coronary artery disease or ischemic stroke |
| THCA | cis | rs7590720 | 1 | rs6435930 | chr2:216885852 | MREG | chr2:216807315-216878346:- | 0.38 | 7.95 | 1.4E-14 | Alcohol dependence |
| THCA | cis | rs7590720 | 1 | rs6435930 | chr2:216885852 | PECR | chr2:216861029-216946532:- | 0.25 | 5.07 | 5.84E-7 | Alcohol dependence |
| THCA | cis | rs11689435 | 1 | rs6435984 | chr2:218314788 | IGFBP5 | chr2:217536829-217560272:- | -0.21 | -4.43 | 1.19E-5 | Metabolite levels (MHPG) |
| THCA | cis | rs523340 | 1 | rs643632 | chr9:111839949 | C9orf5 | chr9:111777416-111882225:- | -0.18 | -3.42 | 0.000681 | Information processing speed |
| THCA | cis | rs59374417 | 1 | rs6438537 | chr3:119277846 | ADPRH | chr3:119298523-119308791:+ | -0.23 | -3.66 | 0.000277 | Vitiligo |
| THCA | cis | rs6805251 | 1 | rs6438552 | chr3:119631814 | GSK3B | chr3:119540804-119813264:- | 0.14 | 4.92 | 1.19E-6 | HDL cholesterol |
| THCA | cis | rs6805251 | 1 | rs6438553 | chr3:119640029 | GSK3B | chr3:119540804-119813264:- | 0.14 | 4.99 | 8.65E-7 | HDL cholesterol |
| THCA | cis | rs73201462 | 1 | rs6439116 | chr3:127849067 | EEFSEC | chr3:127872313-128127488:+ | -0.26 | -4.47 | 9.77E-6 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio |
| THCA | cis | rs73201462 | 1 | rs6439124 | chr3:128007466 | EEFSEC | chr3:127872313-128127488:+ | 0.27 | 4.82 | 1.91E-6 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio |
| THCA | cis | rs10935120 | 1 | rs6439484 | chr3:134249899 | ANAPC13 | chr3:134196547-134204865:- | 0.39 | 12.58 | 1.56E-31 | Height |
| THCA | cis | rs10935120 | 1 | rs6439484 | chr3:134249899 | CEP63 | chr3:134204575-134293852:+ | 0.3 | 6.54 | 1.63E-10 | Height |
| THCA | cis | rs10935120 | 1 | rs6439487 | chr3:134260860 | ANAPC13 | chr3:134196547-134204865:- | 0.39 | 12.58 | 1.56E-31 | Height |